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Profile

Sytheon is an innovative research-based company committed to developing high-performance active ingredients for the personal care industry since 2006. 

Every active ingredient in the Sytheon portfolio is inspired by nature and “Built for Performance.” Moreover, all active ingredients are scientifically and clinically validated to improve the health and beauty of the skin.

We focus on developing multifunctional ingredients. Use of multifunctional ingredient is the smart way to increase performance and sustainability and reduce complexity of formulations.


 Press Releases

  • Tetrahexyldecyl Ascorbate (THDC) degrades rapidly under oxidative stress but can be stabilized by acetyl zingerone to enhance collagen production and antioxidant effects, International J Molecular Sciences, 22:8756, 2021


    The Facts
    The topical delivery of Vitamin C (VC) holds longstanding challenges due to its poor stability and dermal penetration. Tetrahexyldecyl Ascorbate (THDC, VitaSynol® C), a lipid-soluble VC precursor esterified with branched chain fatty acid (2-hexyldecanoic acid), is reported to have an improved stability and ability to penetrate the lipophilic stratum corneum. This essentially makes THDC a pro-drug that facilitates delivery to the dermis where it may then undergo intracellular enzymatic conversion to release VC. As a result, THDC has garnered widespread interest and use within the cosmetics industry even though the molecule comprises only 15.5% VC, which means that in order to deliver 1% VC to skin at least 6.5% THDC would be required in a formulation assuming 100% conversion to VC.


    Study Results
    Our study revealed that THDC, itself, is a poor antioxidant and undergoes rapid degradation when exposed to singlet oxygen, a well-recognized mediator of oxidative stress within skin. Interestingly, we observed that THDC degradation by singlet oxygen could be prevented by combining it with Synoxyl® AZ (Acetyl Zingerone, AZ) as a stabilizing antioxidant (non-sacrificing). Also, while THDC lacked ability to improve viability of HaCaT Keratinocytes exposed to oxidative stress (H2O2), combining THDC with AZ bestowed complete protection.
    In gene expression studies using RHE (Reconstituted Human Epidermis, EpiDerm FT tissues, Mattek, Microarray), treatment with THDC as a standalone ingredient led to unexpected activation of type I interferon signaling, the unhealthy skin gene signature, as well as the pro-inflammatory STAT1-57 gene module, all of which were abrogated when THDC was combined with AZ. Activation of the type I interferon pathway plays important roles in antiviral defense responses, wounding and skin cancers, in addition to a broad spectrum of other skin diseases. To our knowledge, no prior studies have demonstrated detrimental pro-inflammatory effects for topically applied THDC as a standalone ingredient. In fact, there is not a single peer reviewed research article available on THDC as a standalone ingredient.
    Synoxyl® AZ + VitaSynol® C: A Perfect Synergistic Mechanism
    Intriguingly, the combination of THDC and AZ also increased expression of skin-friendly genes associated with phospholipid homeostasis and keratinocyte differentiation, along with repression of MMP1 and MMP7 expression, inhibition of MMP enzyme activity and increased production of collagen proteins by dermal fibroblasts.
    These results support a synergistic mechanism by which AZ can stabilize THDC to facilitate and improve delivery of VC into the dermis and otherwise buffer against aberrant activation of genes associated with skin dysfunction and breakdown caused by THDC alone. This provides a step towards reaching the full potential of ascorbate as an active ingredient in topical preparations.


    For more information, please contact info@syhthonltd.com

  • Publication: T Meyer & RK Chaudhuri, Omni Antioxidant: Acetyl Zingerone scavenges/quenches reactive species, selectively chelates iron, C&T, October 2020 

    Abstract: A multifunctional ingredient whose design was inspired by Zingerone from ginger in nature. Synoxyl® AZ exhibits high efficiencies to neutralize all reactive oxygen species (ROS) (including 1O2, -OONO, and OH). This is important since daily exposure to environmental stressors keeps skin under a persistent burden of excess ROS, which drives premature skin aging. The present article explores the multiple benefits of Acetyl Zingerone, as a single ingredient, to proactively manage excess ROS production in skin via sacrificial (i.e., chemical) and non-sacrificial (i.e., physical) pathways.  The ability of Acetyl Zingerone to neutralize ROS through non-sacrificial pathways provides longer-lasting performance and differentiates it from many conventional antioxidants.  Moreover, AZ is not a pro-oxidant and is photochemically stable in contrast to commonly used antioxidants such as Vitamin C, Vitamin E, and Resveratrol.  Synoxyl® AZ thus represents a true translational step forward in development of more efficacious molecules to treat or prevent the consequences of intrinsic and extrinsic skin aging through superior management of excess ROS production.

    About Synoxyl® AZ: Consistent with these findings, other studies document that AZ (1) significantly attenuates intracellular ROS in keratinocytes under exposure to UVA radiation (Int J Cosmet Sci 42 (1) 36-45, 2020) (2) inhibits DNA dimer formation in melanocytes after UV ends possibly by scavenging peroxynitrite as a key precursor involved in the process (Int J Cosmet Sci 42 (1) 36-45) (3) improves extracellular matrix integrity with retinoid-like effects based on genomic and transcriptomic studies ((J Invest Dermatol 140 602-614, 2020) and (4) visibly improves the signs of facial photoaging following daily application of lotion containing 1% AZ over 8-weeks compared with its placebo lotion. Additionally, AZ balances skin microbiome diversity and stimulates skin friendly Staph. epidermidis by >20% (J Cosmet Dermatol Available at doi: 10.1111/JOCD.13464, 2020).

    For more information, please contact info@sytheonltd.com


 Products

  • Synoxyl® AZ
    Microbiome Friendly 24/7 Prevention & Repair of Skin Damage...

  • Acetyl Zingerone is a multi-targeted antiaging molecule designed to counteract aging before it happens and to reverse key signs of photo-damaged skin. It prevents skin damage and nurtures skin’s own ability to maintain the integrity of the ECM for optimal health and appearance throughout life.

    Key attributes:

    1. Omni Antioxidant- scavenges/quenches reactive species & selectively chelates iron – First-in-the Industry
    2. Reduces both immediate & delayed skin damage (↓CPDs) First-in-the Industry
    3. Photochemically stable antioxidant in contrast to many conventional antioxidants
    4. Placebo-controlled clinical studies revealed significant improvement in skin defense & reduction in wrinkle, pigmentation and skin redness in photo-aged skin without using sunscreens
    5. Balances skin microbiome diversity and stimulates skin friendly Staphylococcus epidermidis by >20%.

    REACH registered. Patented product.

    Synoxyl® AZ thus provides a translational step forward towards development of a more efficacious molecule to treat or prevent the consequences of intrinsic and extrinsic skin aging.

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